Article

PERM1 Gene Delivery via AAV Prevents Heart Failure in a Mouse Model of Pressure Overload

2025-09-30

Abstract excerpt

Heart failure with reduced ejection fraction (HFrEF) remains a leading cause of mortality worldwide. A hallmark of HFrEF is impaired cardiomyocyte contractility accompanied by disrupted mitochondrial bioenergetics; however, no current therapy targets both pathologies simultaneously. PERM1, a striated muscle-specific regulator of mitochondrial bioenergetics, is downregulated in HFrEF patients. We recently demonstra...

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Literature Corpus work: c62ef6ed-50f1-5671-a824-47bb17cebce6
DOI: 10.1101/2025.09.29.679055

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