Article

Sex–Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation

2026-08-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Moderate to severe tricuspid regurgitation (TR) affects approximately 1.6 million Americans, yet more than 90% of patients with significant TR remain untreated. Women exhibit higher TR prevalence and more rapid disease progression than men, but the valve-intrinsic mechanisms underlying these sex disparities remain unclear. We hypothesized that sex and circulating testosteron...

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Literature Corpus work: a850dc12-009b-5fcd-bbb6-0bf551edae69
DOI: 10.64898/2026.08.05.743037

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