Article
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.
Cancer discovery - 1 Jul 2011
Ying Haoqiang, Elpek Kutlu G, Vinjamoori Anant, Zimmerman Stephanie M, Chu Gerald C, Yan Haiyan, Fletcher-Sananikone Eliot, Zhang Hailei, Liu Yingchun, Wang Wei, Ren Xiaojia, Zheng Hongwu, Kimmelman Alec C, Paik Ji-hye, Lim Carol, Perry Samuel R, Jiang Shan, Malinn Brian, Protopopov Alexei, Colla Simona, Xiao Yonghong, Hezel Aram F, Bardeesy Nabeel, Turley Shannon J, Wang Y Alan, Chin Lynda, Thayer Sarah P, DePinho Ronald A
Abstract excerpt
Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression is associated with frequent loss of tumor suppressors. In this study, human PDAC genome analyses revealed frequent deletion of the PTEN gene as well as loss of expression in primary tumor specimens. A potential role for PTEN as a haploinsufficient tumor suppressor is further supported by mouse...
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