Article

The TLR9-CXCL2 Complex Orchestrates mtDNA-Driven Breg Dysfunction in Acute Lung Injury

2026-05-12

Abstract excerpt

<title>Abstract</title> <p>Background Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints remains undefined. Methods We integrated clinical data from ARDS patients with mechanistic studies...

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Literature Corpus work: 21ce9e05-b276-524d-a03f-0b23457a0031
DOI: 10.21203/rs.3.rs-9438585/v1

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The TLR9-CXCL2 Complex Orchestrates mtDNA-Driven Breg Dysfunction in Acute Lung InjuryDOI 10.21203/rs.3.rs-9438585/v1Read

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