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Article

Transcriptional and posttranscriptional regulation of the SMC-selective blood pressure-associated gene, ARHGAP42.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2020

Mangum Kevin D, Freeman Emily J, Magin Justin C, Taylor Joan M, Mack Christopher P

Abstract excerpt

We previously showed that ARHGAP42 is a smooth muscle cell (SMC)-selective, RhoA-specific GTPase activating protein that regulates blood pressure and that a minor allele single nucleotide variation within a DNAse hypersensitive regulatory element in intron1 (Int1DHS) increased ARHGAP42 expression by promoting serum response factor binding. The goal of the current study was to identify additional transcriptional...

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Identifiers

PMID: 31886719
DOI: 10.1152/ajpheart.00143.2019
PMCID: PMC7052622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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