Programming smooth muscle plasticity with chromatin dynamics.

doi:10.1161/01.RES.0000266448.30370.a0

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Article

Programming smooth muscle plasticity with chromatin dynamics.

Circulation research - 25 May 2007

McDonald Oliver G, Owens Gary K

Abstract excerpt

Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid adaptation to fluctuating environmental cues. For example, vascular SMCs undergo profound changes in their phenotype during neointimal formation in response to vessel injury or within atherosclerotic plaques. Recent studies have shown that interaction of serum response factor (SRF) and its numerous accessory cofactors with CArG...

Topics

Acetylation
Animals
Becaplermin
Cell Differentiation
Chromatin
DNA
Histones
Humans
Methylation
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet-Derived Growth Factor

Promoter Regions, Genetic

Proto-Oncogene Proteins c-sis

Serum Response Factor

Signal Transduction

Transcription, Genetic

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Open in PubMed

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PMID: 17525382
DOI: 10.1161/01.RES.0000266448.30370.a0

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