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Article

MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Zhao Hanqing, Wen Guanmei, Wen Guammei, Huang Yuan, Yu Xiaotian, Chen Qishan, Afzal Tayyab Adeel, Luong Le Anh, Zhu Jianhua, Ye Shu, Shu Ye, Zhang Li, Xiao Qingzhong

Abstract excerpt

OBJECTIVE: In this study, we attempted to uncover the functional impact of microRNA-22 (miR-22) and its target gene in smooth muscle cell (SMC) differentiation and delineate the molecular mechanism involved. APPROACH AND RESULTS: miR-22 was found to be significantly upregulated during SMC differentiation from embryonic stem cells and adventitia stem/progenitor cells. Enforced expression of miR-22 by its mimic,...

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Source

Identifiers

PMID: 25722434
DOI: 10.1161/ATVBAHA.114.305212

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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