Article
Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
The Journal of clinical investigation - 1 Feb 2017
Bai Xue, Mangum Kevin D, Dee Rachel A, Stouffer George A, Lee Craig R, Oni-Orisan Akinyemi, Patterson Cam, Schisler Jonathan C, Viera Anthony J, Taylor Joan M, Mack Christopher P
Abstract excerpt
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure-associated locus within the ARHGAP42 gene. The goals of the current study were to identify polymorphisms that affect ARHGAP42 expression and to better assess ARHGAP42's role in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.