Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.

Circulation research - 2 May 2003

Kumar Meena S, Hendrix Jennifer A, Johnson A Daniel, Owens Gary K

Abstract excerpt

Changes in the differentiated state of smooth muscle cells (SMCs) play a key role in vascular diseases, yet the mechanisms controlling SMC differentiation are still largely undefined. We addressed the role of basic helix-loop-helix (bHLH) proteins in SMC differentiation by first determining the role of two E-box (CAnnTG) motifs, binding sites for bHLH proteins, in the transcriptional regulation of the SMC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Helix-Loop-Helix Motifs

Share to Lac Operon

Share to Muscle, Smooth, Vascular

Share to Serum Response Factor

Share to Twist-Related Protein 1

Source

Identifiers

PMID: 12663487
DOI: 10.1161/01.RES.0000069031.55281.7C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.PMID 12663487Read ↗

DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.Semantic proximity Read ↗

Differential activation of the SMalphaA promoter in smooth vs. skeletal muscle cells by bHLH factors.Semantic proximity Read ↗

SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with MyocardinSemantic proximity Read ↗

A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages.Semantic proximity Read ↗

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression.Semantic proximity Read ↗

BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene.Semantic proximity Read ↗

Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype.Semantic proximity Read ↗

The mechanism of stem cell differentiation into smooth muscle cellsSemantic proximity Read ↗

Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype.Semantic proximity Read ↗

Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β <sub>1</sub> Signaling in a CArG Box-Independent MannerSemantic proximity Read ↗

Leiomodin 1, a New Serum Response Factor-dependent Target Gene Expressed Preferentially in Differentiated Smooth Muscle CellsSemantic proximity Read ↗

Programming smooth muscle plasticity with chromatin dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.