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Article

Unique molecular signature in mucolipidosis type IV microglia

1 Dec 2019

Abstract excerpt

Abstract Background Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depending on the affected metabolic pathway, LSD manifest with somatic or central nervous system (CNS) signs and symptoms. Neuroinflammation is a hallmark feature of LSD with CNS involvement...

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Share to Calcium signaling and nucleotide metabolism
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PMID: 31883529
DOI: 10.1186/s12974-019-1672-4

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