Article

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

2024-02-02

Abstract excerpt

<h4>Background</h4> Microglia are the primary brain cell type regulating neuroinflammation and they are important for healthy aging. Genes regulating microglial function are associated with an increased risk of neurodegenerative disease. Loss-of-function mutations in CLN3 , which encodes an endolysosomal membrane protein, lead to the most common childhood-onset form of neurodegeneration, featuring early-stage ne...

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Literature Corpus work: 16faef89-1c79-5fa0-a2cf-a591b64a0e7d
DOI: 10.1101/2024.02.01.578018

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