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Article

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

24 Feb 2021

Abstract excerpt

Abstract Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1 , resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain not fully characterized. We discovered pathological proteomic signatures and phenotypes in NPC1-deficient murine models...

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PMID: 33627648
DOI: 10.1038/s41467-021-21428-5

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