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Article

Overview of immune abnormalities in lysosomal storage disorders.

Immunology letters - 1 Aug 2017

Rigante Donato, Cipolla Clelia, Basile Umberto, Gulli Francesca, Savastano Maria Cristina

Abstract excerpt

The critical relevance of the lysosomal compartment for normal cellular function can be proved by numbering the clinical phenotypes that arise in lysosomal storage disorders (LSDs), a group of around 70 different monogenic autosomal or X-linked syndromes, caused by specific lysosomal enzyme deficiencies: all LSDs are characterized by progressive accumulation of heterogeneous biologic materials in the lysosomes of...

Topics

Animals
Autoimmunity
Autophagy
Disease Susceptibility
Genetic Predisposition to Disease
Humans
Inflammation
Lysosomal Storage Diseases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28687233
DOI: 10.1016/j.imlet.2017.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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