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Article

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.

Molecular neurodegeneration - 26 Nov 2024

Clarke Benjamin E, Ziff Oliver J, Tyzack Giulia, Petrić Howe Marija, Wang Yiran, Klein Pierre, Smith Claudia A, Hall Cameron A, Helmy Adel, Howell Michael, Kelly Gavin, Patani Rickie

Abstract excerpt

BACKGROUND: Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the role of microglia in ALS/FTD remains incompletely understood. METHODS: Here, we generated highly enriched cultures of VCP mutant microglia derived from human induced pluripotent stem cells (hiPSCs) to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39593143
DOI: 10.1186/s13024-024-00773-1
PMCID: PMC11590569

Genes

VCP
GPNMB
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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