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Article

A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2020

McGarry Kevin G, Lalisse Remy F, Moyer Robert A, Johnson Kristyn M, Tallan Alexi M, Winters Tyson P, Taris Joeseph E, McElroy Craig A, Lemmon Erin E, Shafaat Hannah S, Fan Yamin, Deal Aniliese, Marguet Sean C, Harvilchuck Jill A, Hadad Christopher M, Wood David W

Abstract excerpt

Chemical warfare nerve agents (CWNAs) present a global threat to both military and civilian populations. The acute toxicity of CWNAs stems from their ability to effectively inhibit acetylcholinesterase (AChE). This inhibition can lead to uncontrolled cholinergic cellular signaling, resulting in cholinergic crisis and, ultimately, death. Although the current FDA-approved standard of care is moderately effective...

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PMID: 31879758
DOI: 10.1093/toxsci/kfz251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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