Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe.

doi:10.1016/j.cbi.2010.01.027

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Article

Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe.

Chemico-biological interactions - 6 Sept 2010

Zheng Xueying, Okolotowicz Karl, Wang Beilin, Macdonald Mary, Cashman John R, Zhang Jun

Abstract excerpt

Nerve agents are highly toxic organophosphorus compounds (OPs) that are used as chemical warfare agents. Developing a catalytic bioscavenger to efficiently detoxify nerve agents in the bloodstream of affected individuals has been recognized as an attractive approach to prevent nerve agent toxicity. However, the search for nerve agent catalysts has been hindered by the lack of efficient direct assays for nerve...

Topics

Animals
Biological Assay
Butyrylcholinesterase
CHO Cells
Calibration
Chemical Warfare Agents
Cricetinae
Cricetulus
Fluorescent Dyes
Humans
Hydrolysis
Mutation
Organophosphorus Compounds
Thiocholine

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Identifiers

PMID: 20097185
DOI: 10.1016/j.cbi.2010.01.027
PMCID: PMC2890299

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