Article
Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity.
Scientific reports - 5 Sept 2017
Larrimore Katherine E, Kazan I Can, Kannan Latha, Kendle R Player, Jamal Tameem, Barcus Matthew, Bolia Ashini, Brimijoin Stephen, Zhan Chang-Guo, Ozkan S Banu, Mor Tsafrir S
Abstract excerpt
Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationally designed to increase the enzyme's ability to hydrolyze the psychoactive enantiomer of cocaine. These variants...
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