Article
Mutations and impaired expression in the ACHE and BCHE genes: neurological implications.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 1994
Soreq H, Ehrlich G, Schwarz M, Loewenstein Y, Glick D, Zakut H
Abstract excerpt
The acetylcholine hydrolysing cholinesterases control the termination of cholinergic signalling in multiple tissues and are targets for a variety of drugs, natural and man-made poisons and common insecticides. Molecular cloning and gene mapping studies revealed the primary structure of human acetyl- and butyrylcholinesterase and localized the corresponding ACHE and BCHE genes to the chromosomal positions 3q26-ter...
Topics
- Acetylcholinesterase
- Butyrylcholinesterase
- Gene Expression Regulation, Enzymologic
- Humans
- Nervous System Diseases
- Phenotype
- Point Mutation