IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

doi:10.1136/annrheumdis-2011-200463

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Mar 2012

Niewold Timothy B, Kelly Jennifer A, Kariuki Silvia N, Franek Beverly S, Kumar Akaash A, Kaufman Kenneth M, Thomas Kenaz, Walker Daniel, Kamp Stan, Frost Jacqueline M, Wong Andrew K, Merrill Joan T, Alarcón-Riquelme Marta E, Tikly Mohammed, Ramsey-Goldman Rosalind, Reveille John D, Petri Michelle A, Edberg Jeffrey C, Kimberly Robert P, Alarcón Graciela S, Kamen Diane L, Gilkeson Gary S, Vyse Timothy J, James Judith A, Gaffney Patrick M, Moser Kathy L, Crow Mary K, Harley John B

Abstract excerpt

OBJECTIVE: High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including IRF5. Genetic variation in IRF5 is associated with SLE susceptibility; however, it is unclear how IRF5 functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Antinuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantibodies

Share to Black or African American

Share to DNA

Share to Interferon-alpha

Share to Interferon Regulatory Factors

Share to Lupus Erythematosus, Systemic

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 22088620
DOI: 10.1136/annrheumdis-2011-200463
PMCID: PMC3307526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.PMID 22088620Read ↗

Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.Semantic proximity Read ↗

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Semantic proximity Read ↗

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Semantic proximity Read ↗

Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus ErythematosusSemantic proximity Read ↗

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus.Semantic proximity Read ↗

A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.Semantic proximity Read ↗

IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.Semantic proximity Read ↗

Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans.Semantic proximity Read ↗

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.Semantic proximity Read ↗

Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population.Semantic proximity Read ↗

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population.Semantic proximity Read ↗

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.