Article
CPI motif interaction is necessary for capping protein function in cells.
Nature communications - 28 Sept 2015
Edwards Marc, McConnell Patrick, Schafer Dorothy A, Cooper John A
Abstract excerpt
Capping protein (CP) has critical roles in actin assembly in vivo and in vitro. CP binds with high affinity to the barbed end of actin filaments, blocking the addition and loss of actin subunits. Heretofore, models for actin assembly in cells generally assumed that CP is constitutively active, diffusing freely to find and cap barbed ends. However, CP can be regulated by binding of the 'capping protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.