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Article

Wash functions downstream of Rho and links linear and branched actin nucleation factors

24 Jul 2009

Abstract excerpt

Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/3 activators that mediate the branched-actin network formation required for cytoskeletal remodeling, intracellular transport and cell locomotion. Wasp and Scar/WAVE, the two founding members of the family, are regulated by the GTPases Cdc42 and Rac, respectively. By contrast, linear actin nucleators, such as Spire and formins, are regulated by the GTPase...

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PMID: 19633175
DOI: 10.1242/dev.035246

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Wash functions downstream of Rho and links linear and branched actin nucleation factorsPMID 19633175Read ↗

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The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance.Semantic proximity Read ↗

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