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Article

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.

Cell reports - 24 Dec 2019

Iannielli Angelo, Ugolini Giovanni Stefano, Cordiglieri Chiara, Bido Simone, Rubio Alicia, Colasante Gaia, Valtorta Marco, Cabassi Tommaso, Rasponi Marco, Broccoli Vania

Abstract excerpt

Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and synaptic terminals. Co-culture of human midbrain dopaminergic and striatal medium spiny neurons on the microchip establishes an orchestrated nigro-striatal circuitry with...

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Identifiers

PMID: 31875567
DOI: 10.1016/j.celrep.2019.11.111
PMCID: PMC6941223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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