Back to search

Article

A system for high-throughput axonal imaging of induced pluripotent stem cell-derived human i <sup>3</sup> Neurons

2025-11-25

Abstract excerpt

Neurons have long, thin axons and branched dendritic processes which rely on an extensive microtubule network that functions as a cellular scaffold and substrate for cargo transport. Microtubule defects are a defining pathological feature of neurological disorders. The highly arborized, long, polarized neuronal processes pose challenges for imaging-based assays. Available methods use either dispersed cultures, whi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ed80db73-4741-57f4-8df5-b734cbab86cb
DOI
10.1101/2025.11.22.689945
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A system for high-throughput axonal imaging of induced pluripotent stem cell-derived human i <sup>3</sup> NeuronsDOI 10.1101/2025.11.22.689945
Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neuronsSemantic proximity
Mass Generation, Neuron Labelling and 3D Imaging of MinibrainsSemantic proximity
Human Tridimensional Neuronal Cultures for Phenotypic Drug Screening in Inherited Peripheral Neuropathies.Semantic proximity
Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes.Semantic proximity
A multimodal 3D neuro-microphysiological system with neurite-trapping microelectrodesSemantic proximity
An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroidsSemantic proximity
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neuronsSemantic proximity
Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturationSemantic proximity
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.Semantic proximity
High-content interrogation of human induced pluripotent stem cell-derived cortical organoid platformsSemantic proximity
A dendritic-like microtubule network is organized from swellings of the basal fiber in neural progenitorsSemantic proximity
The Shift from 2D to 3D Cell Culture in Neurobiology: Implications for Precision Medicine and Organ-on-Chip TechnologiesSemantic proximity
Select a neighboring publication to make it the new centre.