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Early striatal hyperexcitability in an <i>in vitro</i> human striatal microcircuit model carrying the Parkinson’s <i>GBA-N370S</i> mutation

2023-03-02

Abstract excerpt

Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia. Here, we developed a custom three-chamber microfluidic platform and established a cortico-striato-nigral microcircuit recapitulating the striatal presynaptic triad in vitro using induced pluripotent stem cell (iPSC)-derived neurons. We found that,...

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Literature Corpus work
3f3b13a1-3e4d-58ea-adca-28f69c9e5eb8
DOI
10.1101/2023.03.01.530566
Open publication

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Early striatal hyperexcitability in an <i>in vitro</i> human striatal microcircuit model carrying the Parkinson’s <i>GBA-N370S</i> mutationDOI 10.1101/2023.03.01.530566
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