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Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis

23 Dec 2019

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal disease and characterized by increased deposition of extracellular matrix proteins and scar formation in the lung, resulting from alveolar epithelial damage and accumulation of inflammatory cells. Evidence suggests that Caveolin-1 (Cav-1), a major component of caveolae which regulates cell signaling and endocytosis, is a potential target to treat...

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Share to Caveolin-1 and cellular processes
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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

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PMID: 31873099
DOI: 10.1038/s41598-019-55819-y

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