Article
Role of caveolin-1 in the pathogenesis of tissue fibrosis by keloid-derived fibroblasts in vitro.
The British journal of dermatology - 1 Mar 2011
Zhang G-Y, Yu Q, Cheng T, Liao T, Nie C-L, Wang A-Y, Zheng X, Xie X-G, Albers A E, Gao W-Y
Abstract excerpt
BACKGROUND: Recent studies have suggested that caveolin-1 (cav-1) plays an important role in the regulation of transforming growth factor (TGF)-β1 signalling and participates in the pathogenesis of tissue fibrosis. However, its effects on dermal fibrosis keloids are unknown. OBJECTIVES: To investigate the effect of cav-1 in the pathogenesis of tissue fibrosis by keloid fibroblasts. METHODS: Keloid fibroblasts...
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