Loss of interferon regulatory factor-1 prevents lung fibrosis by upregulation of pon1 expression

Abstract excerpt

Interferon regulatory factor-1 (IRF1) is a transcription factor that plays a significant role in various biological processes, including inflammatory injury, viral infection, cell death, and immune responses, and it has been extensively studied in the context of different lung diseases. However, the mechanism underlying its involvement in lung fibrosis remains largely unknown. Wild type (WT) mice, IRF1...

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