Article

An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation

2022-04-12

Abstract excerpt

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective Ca 2+ permeable cation channel, which was originally cloned from human lung fibroblasts (HLFs). TRPA1-mediated Ca 2+ entry is evoked by exposure to several chemicals, including allyl isothiocyanate (AITC), and a protective effect of TRPA1 activation in the development of cardiac fibrosis has been proposed. Yet, the function of TRPA1 in transformin...

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Literature Corpus work: 9f8bfc9b-c5c3-5984-a465-f4b53a7ecec2
DOI: 10.1101/2022.04.12.488008

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