Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.

Respiratory research - 27 Mar 2015

Bernau Ksenija, Ngam Caitlyn, Torr Elizabeth E, Acton Benjamin, Kach Jacob, Dulin Nickolai O, Sandbo Nathan

Abstract excerpt

BACKGROUND: Fibrosing disorders of the lung, such as idiopathic pulmonary fibrosis, are characterized by progressive extracellular matrix accumulation that is driven by myofibroblasts. The transcription factor megakaryoblastic leukemia-1 (MKL1) mediates myofibroblast differentiation in response to several profibrotic stimuli, but the role it plays in mediating pulmonary fibrosis has not been fully elucidated. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bleomycin
Share to Bronchoalveolar Lavage Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Shape

Share to Collagen

Share to Fibronectins

Share to Inflammation Mediators

Share to Neutrophil Infiltration

Share to Pulmonary Fibrosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25885656
DOI: 10.1186/s12931-015-0206-6
PMCID: PMC4392778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.PMID 25885656Read ↗

Extracellular Matrix Remodeling Associated with Bleomycin-Induced Lung Injury Supports Pericyte-To-Myofibroblast TransitionSemantic proximity Read ↗

Extracellular matrix remodeling associated with bleomycin-induced lung injury supports pericyte-to-myofibroblast transitionSemantic proximity Read ↗

Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.Semantic proximity Read ↗

IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model.Semantic proximity Read ↗

CREPT is required for pulmonary fibrosis induced by bleomycinSemantic proximity Read ↗

Bleomycin mouse model with active-phase pulmonary fibrosis and no acute mortalitySemantic proximity Read ↗

GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosisSemantic proximity Read ↗

Therapies for bleomycin induced lung fibrosis through regulation of TGF‐β1 induced collagen gene expressionSemantic proximity Read ↗

Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosisSemantic proximity Read ↗

Transcriptomics of acute injured lungs reveals IGF1R action on DNA damage response, metabolic reprogramming, mitochondrial homeostasis and epigeneticsSemantic proximity Read ↗

Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.Semantic proximity Read ↗

Highly Calibrated Relationship Between Bleomycin Concentrations and Facets of the Active Phase Fibrosis in Classical Mouse Bleomycin ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.