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Article

Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA.

PloS one - 8 Jun 2010

Xu Yaqin, Krause Anja, Hamai Hiroko, Harvey Ben-Gary, Worgall Tilla S, Worgall Stefan

Abstract excerpt

The inflammatory milieu in the respiratory tract in cystic fibrosis (CF) has been linked to the defective expression of the cystic transmembrane regulator (CFTR) in epithelial cells. Alveolar macrophages (AM), important contibutors to inflammatory responses in the lung, also express CFTR. The present study analyzes the phenotype of human AM with silenced CFTR. Expression of CFTR mRNA and the immature form of the...

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Identifiers

PMID: 20543983
DOI: 10.1371/journal.pone.0011004
PMCID: PMC2882373

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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