Article
Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival.
Bioscience reports - 31 Jan 2020
Chen Xiao, Theobard Rutaganda, Zhang Jianying, Dai Xiaofeng
Abstract excerpt
RAD50 is commonly depleted in basal-like breast cancer with concomitant absence of INPP4B and several tumor suppressors such as BRCA1 and TP53. Our previous study revealed that INPP4B and RAD50 interact and such an interaction is associated with breast cancer survival at the transcriptional, translational and genomic levels. In the present study, we explored single nucleotide polymorphisms (SNPs) of these two...
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