Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium.

doi:10.1093/aje/kwu214

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Article

Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium.

American journal of epidemiology - 15 Nov 2014

Joshi Amit D, Lindström Sara, Hüsing Anika, Barrdahl Myrto, VanderWeele Tyler J, Campa Daniele, Canzian Federico, Gaudet Mia M, Figueroa Jonine D, Baglietto Laura, Berg Christine D, Buring Julie E, Chanock Stephen J, Chirlaque María-Dolores, Diver W Ryan, Dossus Laure, Giles Graham G, Haiman Christopher A, Hankinson Susan E, Henderson Brian E, Hoover Robert N, Hunter David J, Isaacs Claudine, Kaaks Rudolf, Kolonel Laurence N, Krogh Vittorio, Le Marchand Loic, Lee I-Min, Lund Eiliv, McCarty Catherine A, Overvad Kim, Peeters Petra H, Riboli Elio, Schumacher Fredrick, Severi Gianluca, Stram Daniel O, Sund Malin, Thun Michael J, Travis Ruth C, Trichopoulos Dimitrios, Willett Walter C, Zhang Shumin, Ziegler Regina G, Kraft Peter

Abstract excerpt

Additive interactions can have public health and etiological implications but are infrequently reported. We assessed departures from additivity on the absolute risk scale between 9 established breast cancer risk factors and 23 susceptibility single-nucleotide polymorphisms (SNPs) identified from...

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PMID: 25255808
DOI: 10.1093/aje/kwu214
PMCID: PMC4224360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25255808-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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