Article
SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.
Oncotarget - 10 Nov 2015
Jamshidi Maral, Fagerholm Rainer, Khan Sofia, Aittomäki Kristiina, Czene Kamila, Darabi Hatef, Li Jingmei, Andrulis Irene L, Chang-Claude Jenny, Devilee Peter, Fasching Peter A, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Guo Qi, Rhenius Valerie, Cornelissen Sten, Rudolph Anja, Knight Julia A, Loehberg Christian R, Burwinkel Barbara, Marme Frederik, Hopper John L, Southey Melissa C, Bojesen Stig E, Flyger Henrik, Brenner Hermann, Holleczek Bernd, Margolin Sara, Mannermaa Arto, Kosma Veli-Matti, Van Dyck Laurien, Nevelsteen Ines, Couch Fergus J, Olson Janet E, Giles Graham G, McLean Catriona, Haiman Christopher A, Henderson Brian E, Winqvist Robert, Pylkäs Katri, Tollenaar Rob A E M, García-Closas Montserrat, Figueroa Jonine, Hooning Maartje J, Martens John W M, Cox Angela, Cross Simon S, Simard Jacques, Dunning Alison M, Easton Douglas F, Pharoah Paul D P, Hall Per, Blomqvist Carl, Schmidt Marjanka K, Nevanlinna Heli
Abstract excerpt
In breast cancer, constitutive activation of NF-κB has been reported, however, the impact of genetic variation of the pathway on patient prognosis has been little studied. Furthermore, a combination of genetic variants, rather than single polymorphisms, may affect disease prognosis. Here, in an extensive dataset (n = 30,431) from the Breast Cancer Association Consortium, we investigated the association of 917...
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