Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathway-based discovery of genetic interactions in breast cancer.

PLoS genetics - 1 Sept 2017

Wang Wen, Xu Zack Z, Costanzo Michael, Boone Charles, Lange Carol A, Myers Chad L

Abstract excerpt

Breast cancer is the second largest cause of cancer death among U.S. women and the leading cause of cancer death among women worldwide. Genome-wide association studies (GWAS) have identified several genetic variants associated with susceptibility to breast cancer, but these still explain less than half of the estimated genetic contribution to the disease. Combinations of variants (i.e. genetic interactions) may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Genome-Wide Association Study
Share to Gonadal Steroid Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Purines

Share to Receptors, Calcitriol

Share to Risk Factors

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28957314
DOI: 10.1371/journal.pgen.1006973
PMCID: PMC5619706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathway-based discovery of genetic interactions in breast cancer.PMID 28957314Read ↗

Discovering genetic interactions bridging pathways in genome-wide association studiesSemantic proximity Read ↗

Breast cancer susceptibility: an integrative analysis of genomic dataSemantic proximity Read ↗

Genome-wide pathway analysis of breast cancer.Semantic proximity Read ↗

Systematic identification of molecular links between core and candidate genes in breast cancer.Semantic proximity Read ↗

Combinatorial analysis of gene regulatory network reveals the causal genetic basis of breast cancer and gene-specific personalized drug treatmentsSemantic proximity Read ↗

dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks.Semantic proximity Read ↗

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits.Semantic proximity Read ↗

Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk.Semantic proximity Read ↗

Assessing SNP-SNP interactions among DNA repair, modification and metabolism related pathway genes in breast cancer susceptibility.Semantic proximity Read ↗

Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities.Semantic proximity Read ↗

Shared genetics between breast cancer and its predisposing diseases identify novel breast cancer treatment candidatesSemantic proximity Read ↗

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.