Article
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Nature genetics - 1 Nov 2012
Orr Nick, Lemnrau Alina, Cooke Rosie, Fletcher Olivia, Tomczyk Katarzyna, Jones Michael, Johnson Nichola, Lord Christopher J, Mitsopoulos Costas, Zvelebil Marketa, McDade Simon S, Buck Gemma, Blancher Christine, Trainer Alison H, James Paul A, Bojesen Stig E, Bokmand Susanne, Nevanlinna Heli, Mattson Johanna, Friedman Eitan, Laitman Yael, Palli Domenico, Masala Giovanna, Zanna Ines, Ottini Laura, Giannini Giuseppe, Hollestelle Antoinette, Ouweland Ans M W van den, Novaković Srdjan, Krajc Mateja, Gago-Dominguez Manuela, Castelao Jose Esteban, Olsson Håkan, Hedenfalk Ingrid, Easton Douglas F, Pharoah Paul D P, Dunning Alison M, Bishop D Timothy, Neuhausen Susan L, Steele Linda, Houlston Richard S, Garcia-Closas Montserrat, Ashworth Alan, Swerdlow Anthony J
Abstract excerpt
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 ×...
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