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Article

Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra.

Neuropharmacology - 1 Apr 2020

Ortiz-Padilla Sergio, Soto-Orduño Elier, Barrios Marisa Escobar, Manjarrez Abril Armenta, Bastián Yadira, Mendez J Alfredo

Abstract excerpt

Dopaminergic neurons have the ability to release Dopamine from their axons as well as from their soma and dendrites. This somatodendritically-released Dopamine induces an autoinhibition of Dopaminergic neurons mediated by D2 autoreceptors, and the stimulation of neighbor GABAergic neurons mediated by D1 receptors (D1r). Here, our results suggest that the somatodendritic release of Dopamine in the substantia nigra...

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Identifiers

PMID: 31870855
DOI: 10.1016/j.neuropharm.2019.107920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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