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Article

Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32.

Neuropharmacology - 1 Apr 2014

Sánchez Natalia, Coura Renata, Engmann Olivia, Marion-Poll Lucile, Longueville Sophie, Hervé Denis, Andrés María E, Girault Jean-Antoine

Abstract excerpt

Impaired dopaminergic signaling in the striatum is involved in diseases as diverse as Parkinson's disease, addiction, and schizophrenia. An important pathophysiological aspect is the loss of balance between striatopallidal and striatonigral pathways. Nur77 is an orphan nuclear receptor and dopamine-regulated immediate-early gene. Classical antipsychotic drugs widely used in the treatment of schizophrenia, such as...

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PMID: 24440754
DOI: 10.1016/j.neuropharm.2014.01.008

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