Article
Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 May 2007
Mijatovic Jelena, Airavaara Mikko, Planken Anu, Auvinen Petri, Raasmaja Atso, Piepponen T Petteri, Costantini Frank, Ahtee Liisa, Saarma Mart
Abstract excerpt
Ret is the common signaling receptor for glial cell line-derived neurotrophic factor (GDNF) and other ligands of the GDNF family that have potent effects on brain dopaminergic neurons. The Met918Thr mutation leads to constitutive activity of Ret receptor tyrosine kinase, causing the cancer syndro...
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