Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling.

PloS one - 1 Jan 2013

Korecka Joanna A, van Kesteren Ronald E, Blaas Eva, Spitzer Sonia O, Kamstra Jorke H, Smit August B, Swaab Dick F, Verhaagen Joost, Bossers Koen

Abstract excerpt

Multiple genetic and environmental factors play a role in the development and progression of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta. To study genetic and molecular contributors to the disease process, there is a great need for readily accessible cells with prominent DAergic features that can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oligonucleotide Array Sequence Analysis
Share to Dopamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dopamine Plasma Membrane Transport Proteins

Share to Dopaminergic Neurons

Share to Neurotransmitter Agents

Share to Norepinephrine Plasma Membrane Transport Proteins

Share to Substantia Nigra

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 23724009
DOI: 10.1371/journal.pone.0063862
PMCID: PMC3665836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling.PMID 23724009Read ↗

Estrogen-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells.Semantic proximity Read ↗

Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell lineSemantic proximity Read ↗

Sub-micromolar concentrations of retinoic acid induce morphological and functional neuronal phenotypes in SK-N-SH neuroblastoma cells.Semantic proximity Read ↗

Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells.Semantic proximity Read ↗

Functional implications of the noradrenergic-cholinergic switch induced by retinoic acid in NB69 neuroblastoma cells.Semantic proximity Read ↗

The BE (2)-M17 cell line has a better dopaminergic phenotype than the traditionally used for Parkinson´s research SH-SY5Y, which is mostly serotonergic.Semantic proximity Read ↗

The BE (2)-M17 cell line has a better dopaminergic phenotype than the traditionally used for Parkinson´s research SH-SY5Y, which is mostly serotonergicSemantic proximity Read ↗

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology.Semantic proximity Read ↗

SH-SY5Y Cell Line In Vitro Models for Parkinson Disease Research—Old Practice for New TrendsSemantic proximity Read ↗

Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5YSemantic proximity Read ↗

Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.Semantic proximity Read ↗

Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation StateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.