Article

Nicotine-mediated recruitment of GABAergic neurons to a dopaminergic phenotype attenuates motor deficits in alpha-synuclein Parkinson’s model

2021-02-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Previous work revealed an inverse correlation between smoking and Parkinson’s disease (PD) that is associated with nicotine-induced neuroprotection of dopaminergic (DA) neurons against nigrostriatal damage in PD primates and rodent models. Nicotine, a neuroactive component of tobacco, can directly alter the activity of midbrain DA neurons and induce non-DA neurons in the sub...

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Literature Corpus work: 2a855f9e-4d4c-5ac3-b12f-c4e3412f5939
DOI: 10.1101/2021.02.15.431290

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