Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.

International journal of molecular sciences - 20 Feb 2023

Lai Jessica IChi, Porcu Alessandra, Romoli Benedetto, Keisler Maria, Manfredsson Fredric P, Powell Susan B, Dulcis Davide

Abstract excerpt

Previous work revealed an inverse correlation between tobacco smoking and Parkinson's disease (PD) that is associated with nicotine-induced neuroprotection of dopaminergic (DA) neurons against nigrostriatal damage in PD primates and rodent models. Nicotine, a neuroactive component of tobacco, can directly alter the activity of midbrain DA neurons and induce non-DA neurons in the substantia nigra (SN) to acquire a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to GABAergic Neurons

Share to Nicotine

Share to Parkinson Disease

Share to Substantia Nigra

Source

Open in PubMed Open full text

Identifiers

PMID: 36835612
DOI: 10.3390/ijms24044204
PMCID: PMC9960650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.PMID 36835612Read ↗

Nicotine-mediated recruitment of GABAergic neurons to a dopaminergic phenotype attenuates motor deficits in alpha-synuclein Parkinson’s modelSemantic proximity Read ↗

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degenerationSemantic proximity Read ↗

Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicitySemantic proximity Read ↗

Transcriptome responses to reduced dopamine in the Substantia Nigra Pars Compacta reveals a potential protective role for dopamineSemantic proximity Read ↗

Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson’s ModelSemantic proximity Read ↗

Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2Semantic proximity Read ↗

Dopaminergic neurons intrinsic to the striatum.Semantic proximity Read ↗

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene ExpressionSemantic proximity Read ↗

Genetically encoded nAChR upregulation is neuroprotective in female parkinsonian miceSemantic proximity Read ↗

α7-nicotinic acetylcholine receptor and mutated α-synuclein interact in motor behavior and nigrostriatal dopamine - findings with potential relevance for a protective effect of cigarette smoking and Parkinson’s diseaseSemantic proximity Read ↗

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease ModelsSemantic proximity Read ↗

α7-Nicotinic Acetylcholine Receptor and Mutated α-Synuclein Interact in Motor Behaviour and Nigrostriatal Dopamine-Findings With Potential Relevance for a Protective Effect of Cigarette Smoking and Parkinson's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.