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Article

Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation.

Journal of molecular and cellular cardiology - 1 Jan 2020

Zhu Yinghong, Ohama Tohru, Kawase Ryota, Chang Jiuyang, Inui Hiroyasu, Kanno Kotaro, Okada Takeshi, Masuda Daisaku, Koseki Masahiro, Nishida Makoto, Sakata Yasushi, Yamashita Shizuya

Abstract excerpt

AIMS: Age-related cardiac hypertrophy and subsequent heart failure are predicted to become increasingly serious problems in aging populations. Progranulin (PGRN) deficiency is known to be associated with accelerated aging in the brain. We aimed to evaluate the effects of PGRN deficiency on cardiac aging, including left ventricular hypertrophy. METHODS AND RESULTS: Echocardiography was performed on wild-type (WT)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31866375
DOI: 10.1016/j.yjmcc.2019.12.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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