Article

TGFβ−induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome

2022-07-27

Abstract excerpt

Cornelia de Lange Syndrome (CdLS) largely caused by mutation of the cohesin loader NIPBL is a rare developmental disorder affecting the formation of many organs. Besides a short body size and neurological defects, more than half of CdLS children feature various cardiac malformations. To mimic the disease and test a therapeutic strategy, we generated a C57/Bl6 Nipbl+/- mouse model of the disease. These mice featur...

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Literature Corpus work: 798a756a-b4d6-59dd-83f9-0e287884a872
DOI: 10.1101/2022.07.26.501526

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