Article
Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.
American journal of physiology. Cell physiology - 15 Jun 2015
Toba Hiroe, de Castro Brás Lisandra E, Baicu Catalin F, Zile Michael R, Lindsey Merry L, Bradshaw Amy D
Abstract excerpt
To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related cardiac inflammation, we studied six groups of mice: young (3-5 mo old), middle-aged (10-12 mo old), and old (18-29 mo old) C57BL/6 wild-type (WT) and SPARC-null (Null) mice (n = 7-10/group). Cardiac function and structure were determined by echocardiography. The left ventricle was used for cytokine gene array and...
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