Article

Progranulin deficiency aggravates aging-induced vascular injury

2025-11-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Significance</h4> Vascular aging is a major contributor to cardiovascular disease, yet the molecular mechanisms of age-associated vascular dysfunction remain incompletely defined. This study reveals a critical role for progranulin (PGRN) in regulating vascular senescence, function, and remodeling during aging. <h4>Methods</h4> We assessed PGRN expression in human and mouse arteries and sen...

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Literature Corpus work: 8d523b32-f94d-5ead-b6a3-52dba45e0399
DOI: 10.1101/2025.11.25.690611

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