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A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice

17 Nov 2022

Abstract excerpt

Abstract The progressive decline of physiological function and the increased risk of age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, the biomarkers that label in vivo senescence at systemic levels are lacking, thus hindering anti-aging applications. In this study, we generate a Glb1 +/m ‒Glb1-2A-mCherry (GAC) reporter...

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PMID: 36396643
DOI: 10.1038/s41467-022-34801-9

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