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Article

Calponin1 inhibits dilated cardiomyopathy development in mice through the εPKC pathway.

International journal of cardiology - 1 May 2014

Lu Dan, Zhang Li, Bao Dan, Lu Yingdong, Zhang Xu, Liu Ning, Ge Wenping, Gao Xiang, Li Hongliang, Zhang Lianfeng

Abstract excerpt

BACKGROUND: Calponin1 (CNN1) is involved in the regulation of smooth muscle contraction in physiological situation and it also expresses abnormally in a variety of pathological situations. We found that the expression of CNN1 decreased significantly in the heart tissue of a cTnT(R141W) transgenic dilated cardiomyopathy (DCM) mouse model and an adriamycin (ADR)-induced DCM mouse model, suggesting that CNN1 is...

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Source

Identifiers

PMID: 24631115
DOI: 10.1016/j.ijcard.2014.02.032

Genes

CNN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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