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Article

Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging.

GeroScience - 1 Jun 2025

Walter Sophia, Baumgarten Patricia, Hegemann Niklas, Häseli Steffen P, Deubel Stefanie, Jelleschitz Julia, Höhn Annika, Berndt Nikolaus, Kuebler Wolfgang M, Grune Jana, Ott Christiane

Abstract excerpt

Research in aging often refers to animal models, particularly C57BL/6J (B6J) mice, considered gold standard. However, B6J mice are distributed by different suppliers, which results in divers substrains exhibiting notable phenotypic differences. To ensure a suitable phenotype of cardiac aging, we performed heart analyses of young (5 months) and old B6J mice (24 months) from two substrains: B6JRj (Janvier) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39885113
DOI: 10.1007/s11357-025-01543-7
PMCID: PMC12181499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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