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Article

Inhibition of α-synuclein aggregation by small heat shock proteins.

Proteins - 1 Oct 2011

Bruinsma Ilona B, Bruggink Kim A, Kinast Karsten, Versleijen Alexandra A M, Segers-Nolten Ine M J, Subramaniam Vinod, Kuiperij H Bea, Boelens Wilbert, de Waal Robert M W, Verbeek Marcel M

Abstract excerpt

The fibrillization of α-synuclein (α-syn) is a key event in the pathogenesis of α-synucleinopathies. Mutant α-syn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides α-syn, Lewy bodies also contain several associated proteins including small heat shock proteins (sHsps). Since α-syn accumulates...

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PMID: 21905118
DOI: 10.1002/prot.23152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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