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Hsp60 and human aging: Les liaisons dangereuses

31 Dec 2012

Abstract excerpt

Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The...

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PMID: 23276948
DOI: 10.2741/4126

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